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Comparing Marginal and Transition Models In The Analysis of Binary Longitudinal Data: a Simulation Study
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F Zayeri   , S Shahsavari , Ar Baghestani , S Jambarsang * 1, V Lohrabian |
| 1- , s.jambarsang@sbmu.ac.ir |
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Abstract: (10686 Views) |
| Introduction: Longitudinal studies widely used in many branches of science, especial-lly medical science. In the past two deca-des, many models have been proposed for the evaluation of such data. These models are also developed to investigate various re-sponse variables such that categorical varia-bles that have many applications in medical research. While many papers have comp-ared the marginal and random effects mo-dels but fewer studies have compared the marginal and transition models.
Materials & Methods: This paper used simulation with different scenarios for corr-elation, sample size and repeated measures and calculated ROC Curve for two models. Then estimated AUC for them and comp-arison was performed.
Findings: If intensity transition for healthy to disease was large and patient remained disease for a long time that is better used transition model to prediction. In addition, in conditions that intensity transition in any status was equal or trends of transition inte-nsity was inverse of position1 that healthy people remained health for a long time and patients recovered quickly, that is better used marginal model.
Discussion & Conclusion: In analysis of longitudinal data for achieving more accur-ate results when purpose of study was pred-iction, that is better intensity transition bet-ween status was considered and then dec-ided which model is choosen. |
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| Keywords: binary data, markov correlation, marginal model, transition model, roc area under curve |
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Full-Text [PDF 723 kb]
(3318 Downloads)
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Type of Study: Research |
Subject:
biostatistics
Received: 2013/03/3 | Accepted: 2013/03/17 | Published: 2013/03/17
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