:: Volume 16, Issue 3 (10-2008) ::
Journal of Ilam University of Medical Sciences 2008, 16(3): 1-10 Back to browse issues page
Relationship of Serum Zinc & Copper Levels with Clogged Coronaries Numbers in atherosclerotic patients
Abstract:   (13185 Views)
Abstract Introduction: Atherosclerosis -the accumulation of lipid deposits within the linings of arteries- is a major cause of death in developed countries. This disease, based on the involved site and its characteristics, induces specific clinical symptoms that may vary. In spite of our knowledge about this disease, however, some of its principal characteristics are unknown. Trace elements , found in human and animal tissues in about mg/kg or less , have a major role in most aspects of substances metabolism in the body so, their role in health , nourishment and disease in human have been proved. Today, it is believed that there is a significant relationship between the level of alteration of these elements and most the diseases such as atherosclerosis. Therefore, this research was undertaken to evaluate the level of copper and zinc in the serum according to the number of coronary stenosis in the patients with coronary atherosclerosis against the control group. Materials & methods: In this research, 243 subjects- including 60 people (25 female, 35 male) with average of 50.55±9.313 years as control group and 183 subjects (52 female, 131 male) with average of 57.38±10.4 years as case group- were examined. According to clinical examinations and angiographic results and based on the numbers of coronary arteries involved (zero, one, two or three), the case and control groups were assigned into the four groups. There was no coronary vessels stenosis in control group. The case and control groups were compared for background and confidence variables. CTA- 2000-- atomic absorption spectrophotometer was used for analysis of trace elements and biochemical parameters were measured with RA-1000 auto-analyzer. Data were analyzed using Version 10.0 of statistic SPSS package and the results were analyzed using T-test and ANOVA. p<0.05 was the spot for statistical significance. Findings: The mean level of copper and zinc serum in control group was 0.848±0.260 PPM and 0.562±0.204 PPM respectively, while in the second group, it was 0.918±0.205 PPM and 0.578±0.208 PPM respectively, and in case of the third group, it was 1.022±0.241 PPM and 0.643±0.182 PPM respectively, and in the fourth group the results were 1.125±0.241 PPM and 0.718±0.211 PPM respectively. The mean level of copper and zinc serum in all the three case groups compared with the control group increased. Such differences in the view of statistical analysis were significant, (p<0.001).The levels of Cu/Zn and Zn/Cu in these patients compared with the control group were Measured. There were no significant differences between them based on the statistical analysis. Conclusion: According to the results of this research and the previous ones, it is important to maintain the normal level of plasma copper and zinc in the serum . Any abnormal changes in these levels in the serum may increase the risk of atherosclerosis.
Keywords: atherosclerosis, trace element, copper, zinc, CAD
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Type of Study: Research | Subject: General
Received: 2009/02/18 | Accepted: 2015/04/20 | Published: 2015/04/20


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Volume 16, Issue 3 (10-2008) Back to browse issues page