Effect of Trans-cinnamic Acid on Cognitive Deficit, Cell Density of CA1/CA3 Regions, and Cholinergic Activity of Hippocampus in Trimethylettin Model of Alzheimer's Disease

Mokhtarkia, Shima; Edalatmanesh, Mohammad Amin

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Volume 31, Issue 1 (4-2023)

Journal of Ilam University of Medical Sciences 2023, 31(1): 1-12

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Effect of Trans-cinnamic Acid on Cognitive Deficit, Cell Density of CA1/CA3 Regions, and Cholinergic Activity of Hippocampus in Trimethylettin Model of Alzheimer's Disease

Shima Mokhtarkia¹

, Mohammad Amin Edalatmanesh ^*

1- Dept of Biology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Dept of Biology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com

Abstract: (620 Views)

Introduction: Trimethyltin (TMT) intoxication is associated with damage to the cholinergic system in the hippocampus. The aim of this study was to evaluate the effect of trans-cinnamic acid on cognitive deficit and cell damage in CA1/CA3 regions of the hippocampus, as well as measure the activity of acetyl choline esterase (AChE) in the hippocampus of a rat model of Alzheimer’s disease (AD).
Material & Methods: In this experimental study, 40 adult male Wistar rats were randomly divided into four groups: control, TMT+Saline, TMT+CIN20, and TMT+CIN40. The AD model was induced by intraperitoneal injection of 8 mg/kg TMT body weight, and 72 h after TMT administration, doses of 20 and 40 mg of trans-cinnamic acid were gavaged daily for four weeks. Subsequently, working memory, passive avoidance learning, neuronal density in hippocampal CA1 and CA3 regions, and AChE enzyme activity were measured in this study.
(Ethic Code: IR.IAU.SHIRAZ.REC.1400.014)
Findings: There was a significant increase in CA1/CA3 neuronal density, percentage of motor frequency, and improved passive avoidance memory in the groups receiving trans-cinnamic acid, compared to the group receiving normal saline. Moreover, AChE enzyme activity in the hippocampus, especially in the TMT+CIN40 group, increased significantly, compared to the TMT+Saline group.
Discussion & Conclusion: It seems that trans-cinnamic acid with AChE inhibitory effects improves cognitive decline and hippocampal cell damage in the TMT model of AD.

Keywords: Acetylcholinesterase, Cinnamic Acid, Dementia, Rat, Trimethylettin

Full-Text [PDF 1287 kb] (356 Downloads)

Type of Study: Research | Subject: biology
Received: 2022/05/17 | Accepted: 2022/10/3 | Published: 2023/04/4

References

1. Mantzavinos V, Alexiou A. Biomarkers for Alzheimer's Disease Diagnosis. Curr Alzheimer Res 2017;14:1149-54. doi: 10.2174/1567205014666170203125942.

2. Weller J, Budson A. Current understanding of Alzheimer's disease diagnosis and treatment. F1000Res 2018;7: F1000 Faculty Rev-1161. doi: 10.12688/f1000research.14506.1.

3. Tönnies E, Trushina E. Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease. J Alzheimers Dis 2017;57:1105-21. doi: 10.3233/JAD-161088.

4. Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer's disease. Brain 2018;141:1917-33.doi: 0.1093/brain/awy132.

5. Gao H, Jiang Y, Zhan J, Sun Y. Pharmacophore-based drug design of AChE and BChE dual inhibitors as potential anti-Alzheimer's disease agents. Bioorg Chem 2021;114:105149.doi: 10.1016/j.bioorg.2021.105149.

6. Ruwizhi N, Aderibigbe BA. Cinnamic Acid Derivatives and Their Biological Efficacy. Int JMolSci2020;215712.doi: 10.3390/ijms21165712.

7. Chandra S, Roy A, Jana M, Pahan K. Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model. Neurobiol Dis 2019; 124:379-95. doi: 10.1016/j.nbd.2018.12.007.

8. Caruso G, Godos J, Privitera A, Lanza G, Castellano S, et al. Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease. Nutrients 2022;14:819. doi: 10.3390/nu14040819.

9. Feng LS, Cheng JB, Su WQ, Li HZ, Xiao T, et al. Cinnamic acid hybrids as anticancer agents: A mini-review. Arch Pharm (Weinheim) 2022; 355:e2200052. doi: 10.1002/ardp.202200052.

10. Edalatmanesh MA, Hosseini M, Ghasemi S, Golestani S, Sadeghnia HR, et al. Valproic acid-mediated inhibition of trimethyltin-induced deficits in memory and learning in the rat does not directly depend on its anti-oxidant properties. Ir J Med Sci 2016;185:75-84. doi: 10.1007/s11845-014-1224-y.

11. Moghadas M, Edalatmanesh MA, Robati R. Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model. Cell J 2016;17:659-67.doi: 10.22074/cellj.2016.3838.

12. Chae HK, Kim W, Kim SK. Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats. Nutrients 2019;11:432. doi: 10.3390/nu11020432.

13. Edalatmanesh MA, Nemati S, Khodabandeh H. Systemic Transplantation Effect of Human Adipose Tissue Derived Mesenchymal Stem Cells on Cognitive Deficits and Hippocampal Antioxidant Capacity in Trimethyltin Model of Alzheimer's Disease. J Ilam Uni Med Sci 2021; 29:32-43. doi: 10.52547/sjimu.29.5.32.

14. Safarpour M, Edalatmanesh MA, Hossini SE, Forouzanfar M. Neuroprotective Effect of Cinnamic Acid on Cognitive Impairment and the Level of Oxidative Stress Indicators in Rat’s Offspring in an Uteroplacental Insufficiency Model. J Ilam Uni Med Sci 2020; 28:33-46. doi: 10.29252/sjimu.28.6.33.

15. Safarpour M, Edalatmanesh MA, Hosseini SE, Forouzanfar M. The effect of cinnamic acid on fetal hippocampus in pregnant rats. Comp Clin Pathol 2020; 29: 945-54. doi:10.1007/s00580-020-03118-8.

16. Han HJ, Park SK, Kang JY, Kim JM, Yoo SK, et al. Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation. Mar Drugs 2021;19:434. doi: 10.3390/md19080434.

17. Shekari A, Fahnestock M. Cholinergic neurodegeneration in Alzheimer disease mouse models. Handb Clin Neurol 2021; 182:191-209. doi: 10.1016/B978-0-12-819973-2.00013-7.

18. Sharma K. Cholinesterase inhibitors as Alzheimer's therapeutics (Review). Mol Med Rep2019;20:1479-87.doi: 10.3892/mmr.2019.10374.

19. Ferreira-Vieira TH, Guimaraes IM, Silva FR, Ribeiro FM. Alzheimer's disease: Targeting the Cholinergic System. Curr Neuropharmacol 2016;14:101-15. doi: 10.2174/1570159x13666150716165726.

20. Ye M, Han BH, Kim JS, Kim K, Shim I. Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model. Int J Mol Sci 2020;21:4901. doi: 10.3390/ijms21144901.

21. McDonald AJ, Mott DD. Functional neuroanatomy of amygdalohippocampal interconnections and their role in learning and memory. J Neurosci Res 2017;95:797-820. doi: 10.1002/jnr.23709.

22. Kim CR, Choi SJ, Kim JK, Park CK, Gim MC, et al. 2,4-Bis(1,1-dimethylethyl)phenol from Cinnamomum loureirii Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice. Biol Pharm Bull 2017;40:932-5. doi: 10.1248/bpb.b16-00997.

23. Chainoglou E, Siskos A, Pontiki E, Hadjipavlou-Litina D. Hybridization of Curcumin Analogues with Cinnamic Acid Derivatives as Multi-Target Agents Against Alzheimer's Disease Targets. Molecules 2020;25:4958. doi: 10.3390/molecules25214958.

24. Jabir NR, Khan FR, Tabrez S. Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease. CNS Neurosci Ther 2018;24:753-62. doi: 10.1111/cns.12971.

25. Hemmati AA, Alboghobeish S, Ahangarpour A. Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice. Korean J Physiol Pharmacol 2018;22:257-67. doi: 10.4196/kjpp.2018.22.3.257.

26. Elufioye TO, Obuotor EM, Agbedahunsi JM, Adesanya SA. Cholinesterase inhibitory activity and structure elucidation of a new phytol derivative and a new cinnamic acid ester from Pycnanthus angolensis. Rev Bras Farmacogn 2016; 26:433‐7. doi: 10.1016/j.bjp.2016.01.010.

27. Lan JS, Hou JW, Liu Y, Ding Y, Zhang Y, et al. Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer's disease. J Enzyme Inhib Med Chem 2017;32:776-88. doi: 10.1080/14756366.2016.1256883.

28. Tadić V, Arsić I, Zvezdanović J, Zugić A, Cvetković D, et al. The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application. J Ethnopharmacol 2017;199:138-48. doi: 10.1016/j.jep.2017.02.002.

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Mokhtarkia S, Edalatmanesh M A. Effect of Trans-cinnamic Acid on Cognitive Deficit, Cell Density of CA1/CA3 Regions, and Cholinergic Activity of Hippocampus in Trimethylettin Model of Alzheimer's Disease. J. Ilam Uni. Med. Sci. 2023; 31 (1) :1-12
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