:: Volume 30, Issue 5 (12-2022) ::
Journal of Ilam University of Medical Sciences 2022, 30(5): 24-31 Back to browse issues page
Comparison of E- cadherin and CD44 Marker Expression in Oral Lichen Planus, Oral Leukoplakia, and Oral Squamous Cell Carcinoma
Khadijeh Abdal1 , Samira Mostafazede1 , Nastaran Ghorbani1 , Mohammadreza Hafeziahmadi * 2
1- Dept of Oral and Maxillofacial Pathology, Faculty of Dentistry, Ilam University of Medical Sciences, Ilam, Iran
2- Associate professor, Department of pathologogy, Faculty of medicine, Ilam University of Medical Sciences, Ilam, Iran. , reza.hafeziahmadi@gmail.com
Abstract:   (669 Views)
Introduction: The role of E-cadherin and CD44 has been proven in the development and progression of cancerous and precancerous lesions. It seems that these two markers have a high ability to evaluate the premalignancy of lichen planus lesions and oral leukoplakia. This study aimed to investigate and compare the expression of CD44 and E-cadherin markers in oral leukoplakia, lichen planus, and oral squamous cell carcinoma (SCC).
Material & Methods: This analytical-descriptive study was conducted on 60 blocks of lichen planus, leukoplakia, and squamous cell carcinoma. The blocks were stained by CD44 and E-cadherin antibodies. The obtained data were analyzed in SPSS software (version 22), and a P-value of 0.05 was considered statistically significant.
Findings: Only 30% of the SCC samples expressed the CD44 marker, while 40% and 50% of leukoplakia and lichen planus samples expressed the CD44 marker, respectively. The expression of the E-cadherin marker in SCC samples was 40% in the range of staining, while it was 50% and 60% in leukoplakia and lichen planus, respectively. There was not a significant difference between the staining intensity of CD44 and E-cadherin (P<0.16). However, in SCC, 70% of the cases showed mild to moderate expression intensity that was statistically significant, compared to lichen planus and leukoplakia (P<0.004).
Discussion & Conclusion: It seems that the severity of CD44 and E-cadherin incidence can indicate the changes in dysplasia and premalignancy of oral lichen planus and leukoplakia, compared to oral carcinomas.
 
Keywords: CD44, E-cadherin, Leukoplakia, Lichen planus, SCC
Full-Text [PDF 1186 kb]   (283 Downloads)    
Type of Study: Research | Subject: Clinical pathology
Received: 2021/11/9 | Accepted: 2022/06/29 | Published: 2022/12/6
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