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:: Volume 30, Issue 2 (6-2022) ::
Journal of Ilam University of Medical Sciences 2022, 30(2): 97-104 Back to browse issues page
Investigation of the Relationship between the rs8192688 Polymorphism of the FABP-4 Gene and Cardiovascular Disease Susceptibility in Type 2 Diabetic Patients in Ilam Province, Iran
Amin Bakhtiyari1 , Salar Bakhtiari * 2, Maryam Peymani1 , Karimeh Haghani1 , Siros Norozi3
1- Dept of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2- Dept of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , bakhtiyaribio@gmail.com
3- Dept of Cardiology, Ilam University of Medical Sciences, Ilam, Iran
Abstract:   (1238 Views)
Introduction: Cardiovascular disease (CVD) is the most common cause of death in patients with type 2 diabetes (T2D). The association between diabetes and cardiovascular disease is complex and multifaceted. This study aimed to investigate the possible association between rs8192688 Polymorphism of the FABP-4 gene and the CVD susceptibility in T2DM patients in Ilam Province, Iran.
Material & Methods: The statistical population consisted of 210 cases (T2D patients with CVD [n=70], T2D patients without CVD [n=70], and healthy controls [n=70]). The frequency of polymorphisms was investigated using the Tetra-Primer-ARMS-PCR method.
(Ethic code: IR.IAU.SHK.1399.011)
Findings: The results showed that TG, HDL-C, and LDL-C in the T2D group with CVD were significantly increased, compared to those in the T2D group (P<0.05). The frequency rates of the CT genotype in the control, T2D, and T2D with CVD groups were 26%, 24%, and 295 (P=0.16), respectively. Moreover, the frequency rates of the TT genotype were 6%, 4%, and 4% (P=0.12), and the frequency rates of the T allele were 19%, 16%, and 19% (P=0.09), respectively. There was no significant relationship between this polymorphism and the studied groups.
Discussion & Conclusion: The results showed that TG, LDL-C, and HDL-C could have a role in the development of CVD in T2D patients; however, the rs8192688 polymorphism of the FABP4 gene was not involved in the development of CVD in T2D patients.
Keywords: Cardiovascular disease, FABP-4, Polymorphism, Type 2 diabetes
Full-Text [PDF 1119 kb]   (433 Downloads)    
Type of Study: Applicable | Subject: biochemistry
Received: 2021/07/17 | Accepted: 2021/07/18 | Published: 2022/06/5
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Bakhtiyari A, Bakhtiari S, Peymani M, Haghani K, Norozi S. Investigation of the Relationship between the rs8192688 Polymorphism of the FABP-4 Gene and Cardiovascular Disease Susceptibility in Type 2 Diabetic Patients in Ilam Province, Iran. J. Ilam Uni. Med. Sci. 2022; 30 (2) :97-104
URL: http://sjimu.medilam.ac.ir/article-1-7189-en.html
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Volume 30, Issue 2 (6-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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