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Impacts of Treatment Management Methods onControl of Toxicity And Side Effects of Chemotherapy Regimens in Breast Cancer
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N Hatam   , P Bastani , N Ahmadloo * 1, AA Ahmadkia Daliri , J Sadeghi far |
| 1- , P_bastani@razi.tums.ac.ir |
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Abstract: (24955 Views) |
| Introduction: Specific effects of chemo-therapy regimens and their side-effects considerably influence on patients lives and their desires of accepting or rejecting therapies. It is obvious that the patient`s idea about the effectiveness of therapy process and accepting the treatment by the patient can facilitate the recovery process greatly. In this study, the side effects and toxicity of Docetaxel-Adriamicine-Cycl-ophosphamide (TAC) and Adriamicine-Cyclophosphamide- 5 FU (FAC) as two chemotherapy regimens were investigated.
Materials & Methods: This investigation was done on a cohort of 100 patients suffering from breast cancer with node- positive being treated with TAC or FAC as a double blind study. Data was gathered by completing special check-lists as interviews at the last session of chemotherapy and surveying the patients` medical records. Data was analyzed by relevant statistical tests such as Independent T-test.
Findings: The results showed that in most the aspects such as amenorrhea, anemia, febrile neutropenia, hyper pigmentation and nail disorder, neurologic toxicity, convul-sion, nomeness and edema, the average mean was higher in TAC arm statistically significant.
Discussion & Conclusion: Applying treat-ment managing approaches tend more to emphasize on patient’s education and im-proving their knowledge before starting chemotherapy cycle, convening of compul-sory consult meetings with expert psychiat-rists and psychologists and establishing su-pportive groups by patients who have recovered from cancer can lead to better and more conscious encountering for such patients and help them accept the therapy more conveniently. |
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| Keywords: toxicity-adjuvant therapy, breast cancer, side effects |
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Full-Text [PDF 190 kb]
(3914 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/05/26 | Published: 2012/04/15
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