:: Volume 14, Issue 4 (1-2007) ::
Journal of Ilam University of Medical Sciences 2007, 14(4): 31-35 Back to browse issues page
The Effect of Intravenous Lidocaine Premedication and Slow Rate of Fentanyl Administration on Fentanyl – Induced Coughing
Abstract:   (14530 Views)
Abstract Introduction: Intravenous (IV) administration of Fentanyl bolus elicits cough in more than one – third of the patients. Coughs may sometimes be explosive leading to hypoxia, vomiting, with increases in intracranial, intraocular and intraabdominal pressures. Materials & Methods: This double blind clinical trial included 360 patients below 60 years with ASA status I & II, who were scheduled for elective surgeries. They were randomized into 3 groups of 120. Group I received Normal Saline as placebo, 60 secounds late fentanyl was administred slowly over a period of 30 secounds. Group II was given fentanyl over 5 secounds, 1 minute after Lidocaine, (1.5 mg/kg IV). Group III also received Normal Salin, 60 secounds before the Fentanyl was given in 5 secounds. Fentanyl dose was 2 µg/kg. Then, incidence and severity of cough was recorded, and the results were analyzed using Chi square test. P.value of 0.05 was considered significant. Results: The incidence of cough was 2.5% in group I, 9.2% and 22.5% in groups II & III respectively. The finds showed that the incidence of cough was significantly higher in group III (P<0.001). Occurrence of cough in patients under 18 was more than those above 18 years of age in all the three groups (P=0.001). Conclusion: IV Lidocaine and, in particular,slow rate of Fentanyl administration, significantly minimize Fentanyl-Induced coughing. Also the incidence of evoked cough is much higher in young patients.
Keywords: : Fentanyl, Cough, Lidocaine, Injection time
Full-Text [PDF 389 kb]   (4711 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/01/27 | Accepted: 2015/04/21 | Published: 2015/04/21

XML   Persian Abstract   Print

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 14, Issue 4 (1-2007) Back to browse issues page