Introduction: This study investigated the electrocatalytic oxidation of amoxicillin on the surface of carbon paste electrode modified with synthesized nano zeolite which was doped with nickel ion in the basic solution. This electrode functions as a sensor to determine amoxicillin.
 
Materials & methods: At first, the percentage of nano zeolite via carbon paste and the flotation of the modified electrode in the nickel chloride solution (1.0 M) for determination of drug were optimized. Then, the determination of amoxicillin in the 0.1 NaOH was conducted using cyclic voltammetry and chronoamprometry techniques.
 
Findings: Obtained results show that the produced NiOOH on the surface of modified electrode acts as an electrocatalyst for the oxidation of amoxicillin. The linear dynamic range and the limit of detection for amoxicillin determination via the proposed electrode were 8.2* 10^-5 M - 2.46* 10^-4 M and 2.3*10^-5 M. The catalytic rate constant for the electro-oxidation of amoxicillin was obtained 4.2*10⁵ cm³s^-1mol^-1.
 
Discussion & conclusions: Finally obtained results reveal that introduced procedure was simple, fast, available, repeatable, and sensetive.