:: Volume 26, Issue 1 (5-2018) ::
Journal of Ilam University of Medical Sciences 2018, 26(1): 34-42 Back to browse issues page
Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural
Mohammad Alizadeh1 , Hamed Khodaei * 2
1- Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Student Research Center, Faculty of nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , hamedkhodaeii@yahoo.com
Abstract:   (4617 Views)

Introduction: 5-Hydroxymethylfurfural (5-HMF) is one of the most important products of the Millard reaction. Several kinds of foods and beverages produce high amount of 5-HMF. In the recent years, many profitable effects of this compound have been demonstrated. Because of the role of T helper cells cytokines in the inflammatory responses, this study sought to investigate the effects of 5-HMF on IFN-γ and IL-4 levels respectively as Th1 and Th2 cytokines in BALB/c mice immunized with ovalbumin (OVA).
Materials & methods: BALB/c mice (n=5 for each group) were grouped as follow:  control, vehicle, and two different treatment groups. The treatment groups received daily doses of 188 and 750 mg/kg body weight, respectively. The groups were immunized with OVA on days 7 and 28 except for the control. Interleukin 4(IL-4) and interferon gamma (IFN-γ) levels were measured in serum by ELISA.
Findings: IL-4 levels were significantly suppressed in 5-HMF treatment groups (P<0.001). IFN-γ levels were significantly lowered in the treatment groups (P<0.05).  Further, no significant difference was observed in IL-4 and IFN-γ levels between the treatment groups (P>0.05).
Discussion & conclusions: 5-HMF reduced production of selected components of Th1 and Th2 cytokine responses in immunized BALB/c mice.

Keywords: 5-hydroxymethylfurfural, cytokine, ovalbumin
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Type of Study: Research |
Received: 2016/07/13 | Accepted: 2017/02/4 | Published: 2018/05/5

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