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:: Volume 25, Issue 4 (11-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(4): 13-23 Back to browse issues page
Effect of Fenugreek on Memory and Learning and also Antioxidant Capacity in Hippocampus of Type II Diabetic Rats
Marjan Moin1 , Seyed Mehrdad Kassaee * 2
1- IAUH, Department of biology
2- Hamedan Branch, Islamic Azad University , kassaee2001@yahoo.com
Abstract:   (6475 Views)

Introduction: Based on the evidences of curing effects of fenugreek on diabetes and its role in strengthening memory and mental health, this study investigated administration of fenugreek extract on learning and memory and also antioxidant level in the hippocampus in type 2 diabetic rats.
Materials & methods: In this study, 24 male rats were divided into 4 groups. Group 1 or control, Group II or diabetic, Group III: diabetic rats treated with 8 gram fenugreek / kg diet, Group IV: diabetic rats treated with 2 gram fenugreek / kg diet. After four weeks, learning and memory were determined using water maze and shuttle box tests. After that, the rats were anesthetised and tissues were removed. Finally, total antioxidant capacity and malondialdehyde were determined in hippocampus.
Findings: Treating diabetic rats with fenugreek extract caused increasing the total antioxidants levels and decreasing the amount of lipid peroxidation in the brain tissue and the dose of 8g/kg was more effective than 2g/kg (p<0.05). The results of studying spatial memory by water maze suggested that the amount of time it takes for the animal to find the hidden platform (escape latency), the distance to find a hidden platform (travel distance) were decreased, and the time remaining in the target quadrant (time in target quadrant) in the treatment group was significantly increased compared to the diabetic one (p<0.05). The results of Passive-avoidance response and memory with shuttle box were showed that Fenugreek extract could reduced the time of remaining in a dark room and increased the step through latency in treated rats compared to diabetic ones (p<0.05).
Discussion & conclusions: Administration of Fenugreek is effective in the capability of maintaining information in the memory stores and reminding them and also increased antioxidant levels in the diabetic rats and relayed mechanism can be prevention of neural cell destruction in hyppocampus due to antioxidant capacity of this plant.

Keywords: Diabetes, Oxidative stress, Fenugreek extract, Memory, Learning
Full-Text [PDF 561 kb]   (1700 Downloads)    
Type of Study: Research |
Received: 2015/10/13 | Accepted: 2016/04/20 | Published: 2017/11/1
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Moin M, Kassaee S M. Effect of Fenugreek on Memory and Learning and also Antioxidant Capacity in Hippocampus of Type II Diabetic Rats. J. Ilam Uni. Med. Sci. 2017; 25 (4) :13-23
URL: http://sjimu.medilam.ac.ir/article-1-3123-en.html

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Volume 25, Issue 4 (11-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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