Introduction: Oxidative stress is defined as an imbalance between the production of free radicals and antioxidants. Oxidative stress is associated with causing chronic diseases such as diabetes and cancer; therefore, production of synthetic and natural antioxidants to prevent oxidative stress and its damaging effects is essential. In this regard nanoparticles synthesized by green method can be used to show antioxidant properties. The aim of this study was to evaluate the antioxidant effect of Silver nanoparticles synthesized by green method from aqueous extract of sumac fruit.

Materials & methods: antioxidant activity of Silver nanoparticles synthesized by green method from aqueous extract of sumac fruit was measured by DPPH (1, 1-diphenyl-2-picrylhydrazyl), ABTS (2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)), and OH (hydroxyl) radical scavenging activity.

Findings: Silver nanoparticles synthesized by green method from aqueous extract of sumac fruit had scavenging activity against DPPH (IC₅₀=170 µM), ABTS (IC₅₀=30 µM) and hydroxyl (IC₅₀=350 µM) free radicals.

Discussion & Conclusions: The results of this study showed that Silver nanoparticles synthesized by green method from aqueous extract of sumac fruit had a strong antioxidant activity. The antioxidant properties of Sumac silver nanoparticles make them valuable in therapy of many diseases caused by oxidative stress and other biomedical applications.