:: Volume 24, Issue 1 (4-2016) ::
Journal of Ilam University of Medical Sciences 2016, 24(1): 133-143 Back to browse issues page
The Efficacity of Abelmoschus esculentus Fruit on Insulin Control in Diabetic Male Wistar Rats
Shahrzad Masoudi * 1, Shahrbanoo Oryan2 , Fakhri-alsadat Hoseini3 , Rozbe Fallahi4
1- Kharazmi University , shahrzad_masoudi@yahoo.com
2- Kharazmi University
3- Alzahra University
4- Razi Vaccine and Serum Research Institute
Abstract:   (7288 Views)

Introduction: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of insulin or both. This study was done to investigate the effects of oral administration of Abelmoschus Esculentus (AE) fruits on blood levels of glucose and insulin in diabetic rats.

Matherials & methods: 25 animals were grouped into five: normal control (NC), diabetic control (DC), and 3 diabetic groups that received 200,400 and 600 mg/kg/body weight of AE powder in their standard food. NC and DC groups fed with standard food. Diabetes mellitus was induced by single doze intraperitoneal injection of streptozotocin 60 mg/kg/body weight in diabetic groups. The period of experiment was 3 weeks after confirming diabetes induction and each group received its particular diet at this time. Blood samples were collected at the end of experiments. Obtained data were analyzed with excel and SPSS software.

Findings: The results indicated that glucose level in DC group not only shows significant growth compared with NC group but also show significant reduction and reaches to normal level in treated diabetic group compared with DC group. Insulin level in DC group shows significant reduction compared with NC group but despite of significant increase of insulin level in each treated diabetic groups, only 200mg/kg bw treated group showed normal level of insulin compared with DC group.

Discussion & Conclusions: Despite of not getting to normal level of insulin in upperdose of treated groups, AE fruit could get glucose to normal levels in each treated groups.

Keywords: Insulin, Abelmoschus esculentus, Diabetes, Rat
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Type of Study: Research | Subject: animal physiology
Received: 2015/05/4 | Accepted: 2015/08/10 | Published: 2016/05/10

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