Introduction: Multiple sclerosis is one of the chronic, non-curable diseases of central nervous system and according to various studies its signs could have a negative impact on quality of life among these patients. Hence, the present study sought to examine the effectiveness of logotherapy on quality of life among MS patients.

Matherials & method: This is an experimental research with pretest- posttest and control group the population included all of patients with MS in Shahrekord in 2013. Cluster sampling was used to select the sample. Instruments which were used in this study included MSQOL-54 inventory for quality of life and group logotherapy.

Results: Results showed that logotherapy is effective on quality of life in MS patients as the 76% increase in dependent variable in this study is quality of life related to effectiveness of group logotherapy.

Discussion & Conclusion: Logotherapy as a technic, with increasing responsibility, transformation of patient's beliefs about life and increasing life expectancy lead to improvement of quality of life in patient with MS in physical and psychological dimensions.

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