Introduction: A variety of sports activities canlead to different immune and hormone responses in human body.The aim of presentstudy was to comparethe acute effects of endurance exercise (EE), resistance exercise (RE) and concurrent exercise (CE) on seruminterleukin-10 (IL-10)and cortisol concentrationand leukocyte numbers in active young men.
Materials & methods: In this study twenty healthy and active young men (mean age: 21.69±2.66years old BMI: 21.92±1.89 Fat%: 14.49±3.05)randomlyand voluntary wereclassified into three groupsincluding: Endurance activity (n=7), Resistance activity ((n=6), Parallel activity(n=7). Theprotocol of three activities simultaneously was performed during 45 minutessimultaneously. Serum concentrationsof IL-10and cortisol were measured by ELISA method and thenumbers of leukocytes were counted before, immediate and 1 hourafteractivity. Data were analyzedbyusing analysis of variance with Repeated-Measures,One-Way ANOVAand LSD post-hoc and Paired T testswith a significant levelp<0.05.
Findings: Serum levels of IL-10 in all three periods were significantly different between three types of exercise including Endurance, Resistance, Parallel exercises. Cortisol response showed significant differencesbetweenthree types of sport activity immediately after exerciseand 1 hour afterexercise. Also, the leukocytesnumbers showedsignificant differencesbetween three types of sport activityimmediately after exercise(p<0.05).
 Discussion & Conclusion: IL-10,cortisol and leukocytesresponses to exercise are dependent ontype of exercise. Also, combination ofResistance and Endurance activitiescan lead to responses from both types of activity and it leads to adjustment of responses to some extent.