Introduction: Aging is one of the most important risk factors for some disease, so that one of the major aims of aging research is the identification and analysis of compounds that playing role in delay aging and increase longevity. In rodents’ Caloric Restriction (CR), in a way that does not cause malnutrition, increased lifespan 50%, however it leave harmful effects, so researchers sought to find a combination that can imitate the effects of CR without any harmful effects. Resveratrol is one of the natural chemicals derived from plants that it is a member of polyphenols family, and it has great antioxidant nature. This article reviews the mechanisms of resveratrol functions on longevity and prevention from aging and aging-related diseases and processes.
 Materials & methods: This study has reviewed 40 published articles by using PubMed, Elsevier, NCBI and EBSCO databases to explaining the resveratrol function in longevity. Findings: Recently, it has been proven that, Resveratrol by delaying all the processes of aging, increased lifespan in many animals in Laboratory model, including fruit flies, nematodes, fishes and mice.
 Discussion & Conclusion: The action mechanism of resveratrol is very similar to CR action mechanism, both can extend lifespan by improving disease related to aging, such as, cardiovascular disease, diabetes, Alzheimer and cancer which this resveratrol effects depended on Sirtuins activity that evolutionarily, they are classified as conserved family of NAD+-dependent class III histone deacetylase, particularly SIRT1, which is the main regulator of molecular mechanism of aging processes.