Introduction: Myeloperoxidase (MPO) has an essential role in the promotion of ather-osclerosis andcoronary artery disease (CA-D). Therefore, this study explored the plasma level of this enzyme in relation to other traditional cardiovascular risk factors in patients with stable and unstable CAD as compared to control subjects. Materials & Methods: In this study, 30 patients with stable CAD, 30 patients with unstable CAD and 30 control subjects were selected based on angiography procedure. Plasma MPO was measured using an imm-unoassay method. High sensitivity C-rea-ctive protein (hsCRP) level was dete-rmined by a latex-enhanced immunot-urb-id-imetric method. Plasma lipid and lip-op-rotein profiles (LDL-cholesterol, HDL-cholesterol, total cholesterol and trigly-cerides) were also determined by enzymatic methods. Other cardiovascular risk factors were also assigned through medical history and questionnaire. Findings:MPO and hsCRP levels were sig-nificantly higher in unstable CAD patients than stable CAD patients. Also, the amou-nts of these two biomarkers were hig-her in stable CAD patients than control subjects (P < 0.01). In patients, MPO level had a significant relationship with hsCRP and the presence of CAD (P < 0.01). Discussion & Conclusion: Elevated level of MPO was a positive independent predictor for the presence of CAD and its plasma le-vels can differentiate between unstable C-AD patients, stable CAD patients and control subjects and may have a diagnostic value.