Modulated Effect of 5-HT4 agonist upon Fear Memory in Dorsal Hippocampus (CA1) in Mice
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M Farrahizadeh * 1, M Zarrindast2 , M Nasehi3 , M Bananej4 |
1- Islamic azad university,north tehran branch , m.farrahizade@gmail.com 2- Institute for Cognitive Science Studies (ICSS) 3- Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Garmsar Branch, Semnan, Iran 4- Islamic azad university,north tehran branch |
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Abstract: (7738 Views) |
Introduction: RS67333 is the selective agonist of 5-HT4 and ACPA (Arachidonylcyclopropylamide) is the selective agonist of CB1. The aim of present study was investigate the bilateral injection effects of dorsal hippocampus (CA1) serotonergic system (Agonist of 5-HT4) on fear memoryformation process induced by ACPA in mature male mice.
Materials & Methods: 120 Male NMRI mice weighting 23-28 gr were put into control and experimental groups in our experiments. Fear conditioning task was used for conditioning of fear. 24 hours after training, we estimated the fear memory formation.
Findings: Intraperitoneal administration of
ACPA (0.005, 0.05 and 0.5 mg/kg) causes impairment of fear memory and amnesia. Moreover, intra-CA1 injection of 5-HT4 receptor agonist (RS67333) (0.005, 0.05 and 0.5 µg/mice) in highest dose impaired fear memory and induced amnesia in saline-treated mice, and increased the impairment of fear memory in ACPA-treated mice(P<0.05).
Diccussion & Conclusion: Serotonergic system (Agonist of 5-HT4) in the CA1 of hippocampus induced by ACPA interferes in the impairment of fear memory.
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Keywords: Cannabinergic system, dorsal hippocampus, RS67333, serotonergic system, fear conditioning task |
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Full-Text [PDF 2490 kb]
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Type of Study: Research |
Subject:
animal physiology Received: 2014/04/20 | Accepted: 2014/05/31 | Published: 2014/11/17
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