Introduction: Type 2 diabetes is a mu-ltifactorial disease and is caused by a variety of genetic and environmental fac-tors. Insulin receptor substrate-1 (IRS-1) is one of the key molecules in the insulins-ignaling pathway so that defects in this protein cause problems in this pathway, de-velops insulin resistance, and eventually leads to type 2 diabetes. The aim of this study was to investigate the association of Gly972Arg polymorphism in IRS-1 gene and type 2 diabetes using meta-analysis.
 Materials & Methods: This was a syste-matic review and meta-analysis study. To find related documents, the following liter-ature databases were searched: Scopus, PubMed, Google scholar, SID, Irandoc and Magiran. Data analysis was performed by STATA software through Random Effects Model. Study heterogeneity was assessed using the I2 index.
Findings: In 9 reviewed papers, the total number of T2D and control subjects was 2462 and 2012, respectively. For the GG, GA, and AA genotypes of the Gly972Arg polymorphism, OR (95% CI) were equal to 1.256 (95% CI=1.08-1.506), 0.075 (0.63-0.893), and 1.481 (0.998-2.197), respect-tively. The results showed that the asso-ciation between the GG and GA genotypes of Gly972Arg polymorphism in IRS-1and susceptibility to T2D was statistically significant (P <0.05).
 Discussion & Conclusion: The results of the present study show an association betw-een GG and GA genotypes of Gly972Arg polymorphism of IRS-1 and type 2 di-abetes.