Introduction: Stigma of mental illness leads to the burden of disease in patients. Due to the stigma of mental illness and the life and behavior, to date, little research has been done in this area the aim of the present study was conducted stigma and its role in the area of patient care in health system.

Materials & methods: In order to find sources of stigma associated with mental illness and health systems, the databases of the National Digital Library of Medicine (Elsevier, psychinfo, Nursing index, Proquest, Scopus, Google scholar) and Persian databases including Irandoc, Iran Medex, Magiran and SID used. A total of 120 articles were obtained, among which 48 articles were selected for review.

Findings:  Results of the study showed that the risk factors and stigma in health care system, according to the review, including the impact of culture, lack of knowledge of health providers with experience in these patients than in patients with poor vision, lack of proper treatment, lack of empathy, communication inappropriate, not taking into account the rights of patients, lack of respect for the privacy of patients.

Discussion & Conclusions: Considering the impact and consequences of stigma in healthcare, nursing managers have to deal with it and reduce the stigma of psychiatric illness in the community focus.