[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations62733583
h-index2719
i10-index18478

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 17, Issue 4 (1-2010) ::
Journal of Ilam University of Medical Sciences 2010, 17(4): 1-8 Back to browse issues page
The effects of L-Arginine and L-Name on corpus luteum and growing follicle changes in pregnant rats
باقر مینایی * , مهناز آذرنیا
Abstract:   (15552 Views)
Introduction: Considering the important role of nitric acid in many biologic processes of cells and tissues including reproduction, in this study we investigated the effects of L-Arginine as a NO formation progenitor and L-Name as a NO formation inhibitor on ovarian corpus luteum and growing follicle changes in pregnant rats. Materials & Methods: Forty female rats of 8 weeks old and 200-250 gr. weight were divided into 5 groups, containing 8 rats in each group upon observing vaginal plaque (It has been considered as zero days at pregnancy).These 5 groups were as follows: Control, Normal Saline, L-Arginine, L-Name and L-Arginine & L-Name. Except the control group, the other groups received normal saline (2 ml/kg/ip), L-Arginine (200mg/kg/lip), L-Name (20mg/kg/lip) and a mixture of two substances for L-Arginine & L-Name group respectively on 3th, 4th, and 5th days of pregnancy. On the 18th day of pregnancy, after anesthesia with ether, laparatomy was performed to separate the mother’s ovaries. Then, the ovaries were fixed in 10% formalin, after tissue passage, the sections were stained with H&E and PAS methods. The changes were observed via light microscopy and graticule. Findings: In the eye of qualitative study, tissue degenerative changes and eruption in most parts of ovaries in L-Arginine group were observed, in quantitative study , the reduction of corpus luteum dimension in mentioned group were seen.(p<0.05) Discussion & Conclusion: Results of this study showed that NO can inhibit the cell growth in pregnancy and induce malfunction in ovary.
Keywords: nitric oxide, ovary, corpus luteum, rat
Full-Text [PDF 627 kb]   (3255 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/05/23 | Accepted: 2015/04/20 | Published: 2015/04/20
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

مینایی ب, آذرنیا م. The effects of L-Arginine and L-Name on corpus luteum and growing follicle changes in pregnant rats. J. Ilam Uni. Med. Sci. 2010; 17 (4) :1-8
URL: http://sjimu.medilam.ac.ir/article-1-159-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 4 (1-2010) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4643