Introduction: Sheng plant with the scientific name Tragopogon graminifolius (T. graminifolius), is used as a wound healer for wounds created in livestock such as sheep and goats in the traditional medicine of Bakhtiari and Lorestan regions ever since ancient times. Since this plant is used in wound healing of livestock by Bakhtiari nomads and as plant compounds do not have the complications of chemical treatments, this study used the T. gram-inifolius extract for wound healing in Lewis race rats. Materials & Methods: The wound was made with puncher skin lesion in 45 male rats and they were randomly divided into 5 groups including control (no treatment), Sham (treated with petroleum jelly) and Experimental1 (exp1/8), experimental 2 (exp1/4), experimental 3 (exp1/2). Exp-erimental groups were treated with 2.5 mg/kg, 5 mg/kg and 10 mg/kg of Trag-opogon extract. Wound healing percent, epidermis thickness, number of macrop-hages, fibroblasts and neutrophils were determined. Data were analyzed using unilateral variance analysis and results were stated based on (ANOVA) using SPSS 11 software and graphs plotted with Excel. Findings: There was a significant increase in wound healing, epidermis thickness, number of macrophages, fibroblasts and neutrophils in experimental groups (2 and 3) in comparison with the shame group (p<0.05). Discussion & Conclusion: Results of this study showed that the external use of T. graminifolius extract has wound healing effects on skin lesion.