Introduction: Somatization symptoms are the obvious physical symptoms without unexplained physical cause. The aim of present study is to examine the relation of psychological variables (alexithymia, negative affect, traumatic events and personality disorder) with somatization symptom in nurses of Ahvaz hospitals.
 Materials & methods: this study is a correlational research. The statistical population included 283 nurses who were selected by multi-stage sampling method. Pearson correlation and regression tests have been used to test the hypotheses.
Findings: Results illustrated that there is a significant relation between alexithymia, negative affect, and traumatic events, personality disorders (antisocial, paranoid histrionic and avoidance) with somatization. Also regression results showed that alexithymia, negative affect, traumatic events and personality disorder (avoidance) were the best predictor of somatization symptoms.
Discussion &Conclusion: Results support from relation between alexithymia, negative affect, traumatic events and personality disorders with somatization symptoms.