:: Volume 22, Issue 4 (9-2014) ::
Journal of Ilam University of Medical Sciences 2014, 22(4): 147-152 Back to browse issues page
The protective effects of zinc on malathion-induced acute oxidative injury in ‎‎blood rats ‎
M Abdolmaleki , H Ghasemi , T Haidari shaiesteh , M Hosaini , A Ranjbar * 1
1- , akranjbar1389@yahoo.com
Abstract:   (7332 Views)
The protective effects of zinc on malathion-induced acute oxidative injury in ‎male rats ‎ Abstract Introduction: Malathion is one of the most toxic organophosphorus insecticides (OPIs). OPIs may induce oxidative stress in various tissues leading to generation of free radicals and alteration in antioxidant system. The objective of this study was to investigate the possible protective effects of Antioxidant effects of zinc were evaluated against malathion-induced oxidative damage in male rat. Materials & Methods: Rats received malathion (250 mg /kg/day, IP) and zinc (5 mg/kg/day, IP) in combination or alone. 20 male rats were equally divided in to 4 groups (5 rats each). Group I (control), while Group II was given malathion. Animals of Groups III received only zinc. Group IV was given zinc+ malathion once for acute test. After treatment, blood was isolated. Cholinestrase activity (ChE) and oxidative stress marker such as total thiol groups (TTG) and total antioxidant capacity (TAC) concentration were measured. Results: Malathion reduced activity of ChE enzyme, TTG and TAC in blood. The changes in TTG and TAC, were restored by zinc. Conclusion:d. It is concluded that oxidative damage is the mechanism of toxicity of malathion that can be recovered by zinc.
Keywords: Malathion, Zinc, Oxidative stress, Rat
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Type of Study: Research | Subject: toxicology
Received: 2013/11/19 | Accepted: 2014/05/12 | Published: 2014/09/9

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Volume 22, Issue 4 (9-2014) Back to browse issues page