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Functionalization of Carboxylated Multi Walled Nanotubes With Diazo Compounds of Aromatic Amins and anti Cancer Study on SW742 Cell Line By Invitro Conditions
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S Haydari kashl   , M Entezari * 1, M Hekmati , S Solaimani |
| 1- , mahdiehentezari63@yahoo.com |
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Abstract: (15655 Views) |
| Introduction: One of the leading causes of death around the world is cancer. Despite the advances in science and technology, man has still failed to cure the disease. The discovery of amazing biological properties of carbon nano tubes caused that they would be good candidates for the research on cancer cells. Functionalization of carbon nanotubes is known to improve their prop-erties. Many compounds that have appli-cations in medicinal chemistry have diazo group. In this paper, we tried to func-tionalize MWNT-COOH with diazo comp-ounds.
Materials & Methods: Modification was confirmed by FT-IR, Raman and SEM spectroscopy. The products were tested on colon cancer cells (SW742) by MTT assay. Viability of the colon cancer cells was investtigated in different concentrations of the functionalized products.
Findings: The results demonstrated that the viability of cancer cells was profoundly de-creased in the presence of the function-nalized nanotubes.
Discussion & Conclusion: Our results reve-aled that the functionalized nanotubes could be a suitable candidate for the synthesis of effective drugs on colon cancer. |
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| Keywords: carbon nanotube, colon center, functionalization |
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Full-Text [PDF 285 kb]
(4906 Downloads)
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Type of Study: Research |
Subject:
Food chemistry
Received: 2013/08/4 | Accepted: 2013/08/6 | Published: 2013/09/1
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