|
The Association Between Telomeres, Telomerase, Cancer and Aging
|
M Hamidi   , N a Ahmadi * 1, S Bastami nejad |
| 1- , nayebalia@sbmu.ac.ir; |
|
|
Abstract: (24637 Views) |
| Telomere is physically terminal of linear chromosomes composed of a non-coding sequence. Mammalian telomeres consist of a variable number of repeated sequences (TTAAGGG) that is added by telomerase to the 3' end of chromosomes. Telomeres pro-tect chromosomes from degradation, chro-mosome attachment to chromosomes and prevent other forms of defective reco-mbination. Despite the contradictory role of telomerase dysfunction in specific genetic diseases, association between telomere dys-function with aging is now open for disc-ussion. The most common way for cancer cells to achieve their specific development into tumor formation is probably through terlomerase activation. Clarify the comple-xities of controlling telomerase may prov-ide a route to target telomerase activity as a routine method of treatment for many pati-ents with cancer and be considered as a target for therapeutics. In this paper, we have a brief look at the structure and fun-ction of telomere and telomerase and then the link between telomerase activity in agi-ng and cancer, and the relationship between different aspects have been investigated in detail. In addition the other roles of telo-merase in the body are discussed. Finally, the use of telomerase as a drug target in cancer therapy has been considered. |
|
| Keywords: telomeres, telomerase, cancer, aging |
|
|
Full-Text [PDF 363 kb]
(8570 Downloads)
|
Type of Study: Research |
Subject:
Bacteriology
Received: 2013/06/2 | Accepted: 2013/09/1 | Published: 2013/09/1
|
|
|
|
|
|
