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Effects of raloxifene on pituitary - ovary axis hormone in adult female rats
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ZAHRA EBADI1   , VAHID HEMAYATKHAH JAHROMI * 2, MOHSEN FOROOZANFAR1 |
1- Azad University
2- Azad University , Dr.hemayatkhah@yahoo.com |
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Abstract: (8681 Views) |
| Abstract
Introduction:Raloxifene is a non-steroidal selective estrogen-receptor modulator which has beneficial estrogen-agonist effects.
Aim:The aim of this study was to evaluate the effect of raloxifene on the pituitary hormone axis in rats.
Materials and Methods:In this study, fourty mature rats of Wistar race weighting 180-200 g and aged 120-130 days had been provided and were divided into 5groups of 8 including control, sham and experimental 1, 2 and 3 groups.
The experimental 1, 2 and 3 groups received raloxifene at doses 30, 60, 120 mg/kg body weight as administered for 4 weeks and the control group did not receive any drug and sham group received distilled water.Injections were done intraperitoneally. After blooding levels of FSH, LH, estrogen and progesterone hormones were measured.
Result:The results of the LH and FSH hormones in experimental 2 and 3 groups indicated significant decrease as compared with control group (P <0/05).the results of the estrogen hormone in the experimental group had no significant difference compared to control and sham groups and progesterone hormone in experimental 3 group indicated significant decrease as compared with control group But not significantly different than control group (P<0/05).
Discussion:The results indicates that raloxifene can disrupt the programming of pituitary-gonadal axis hormone function and have an esterogenic activity in secretion gonadotropin hormone in adult female rats. |
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| Keywords: Key word: Raloxifene, LH, FSH, estrogen, progestrone |
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Full-Text [PDF 396 kb]
(2576 Downloads)
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Type of Study: Research |
Subject:
physiology
Received: 2013/05/21 | Accepted: 2013/10/20 | Published: 2014/02/3
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