[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations62753585
h-index2719
i10-index18578

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 20, Issue 5 (3-2013) ::
Journal of Ilam University of Medical Sciences 2013, 20(5): 121-128 Back to browse issues page
Evaluation of radio-sensitizing effect of TiO2 nanoparticles on human gastric cancer cell line
E Dovlat , H Hasanzadeh * 1, M Rezaei Tavirany , V Semnani , A Jabari arfaee , S Seyyedi , L Jafarzadeh
1- , Hasanzadeh.h@sem-ums.ac.ir
Abstract:   (16391 Views)
Introduction: Nowadays, cancer is the second cause of mortality in the world. Gastric cancer has a high mortality rate (about 70%) which is more common in men and has a higher incidence in eastern Asian countries. One of the methods for cancer treatment is radiotherapy, in which to enhance the efficiency of radiation therapy some of radio-sensitizer agents can be used to enhance tumor cell radiosensitivity. Some nanoparticles can be considered as a sensitizer because of enhancing the cytotoxicity to oxidative stress and increasing free radicals especially ROS within cells, resulting to cell death. In this study, synergistic effect of TiO2 nanoparticles as a radio-sensitizer agent was evaluated in the presence of cobalt-60 gamma rays on human gastric cancer cell line. Materials and Methods: After cell culture, MKN-45 cells were exposed to 2 Gy of radiation and 30 µg/ml concentration of nanoparticles. Viability was calculated using MTT assay. Findings: Exposing cultured cells to nanoparticles alone resulted to a mean decrease of 70% in cell survival. Viability of cells in presence of gamma radiation and nanoparticles was significantly reduced compared to the viability of cells exposed only to radiation or nanoparticle, alone. The effect was dependent both on the nanoparticle crystal type and concentration. Discussion & Conclusion: Nano-TiO2 increased the sensitivity of gastric cancer cells to gamma radiation, due to an increase in the ROS production and cytotoxicity. Anatase crystals have more severe effects than rutile crystal because of having a larger surface area and creation of more free radicals. Therefore, this nanoparticle has the potential to be used as a radio-sensitizer.
Keywords: nano-TiO2, Cobalt 60, gastric cancer, radiosensitivity, radiotherapy
Full-Text [PDF 212 kb]   (3128 Downloads)    
Type of Study: Research | Subject: Bacteriology
Received: 2013/05/20 | Published: 2013/03/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

dovlat E, hasanzadeh H, Rezaei Tavirany M, semnani V, jabari arfaee A, seyyedi S et al . Evaluation of radio-sensitizing effect of TiO2 nanoparticles on human gastric cancer cell line. J. Ilam Uni. Med. Sci. 2013; 20 (5) :121-128
URL: http://sjimu.medilam.ac.ir/article-1-1008-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 5 (3-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4643