TY - JOUR T1 - Study of the Effects of Lactoferrin in Reduction of Cyclophosphamide-induced Embryotoxicity: In Vitro Fertilization Study in Mouse TT - بررسی اثرات لاکتو فرین در کاهش مسمومیت رویانی ناشی از سیکلو فسفامید: مطالعه باروری آزمایشگاهی در موش JF - sjimu JO - sjimu VL - 25 IS - 5 UR - http://sjimu.medilam.ac.ir/article-1-4422-en.html Y1 - 2018 SP - 100 EP - 107 KW - : Cyclophosphamide KW - Lactoferrin KW - Fertility KW - Mouse N2 - Introduction: Cyclophosphamide (CP) as a widely used chemotherapeutic agent causes several side effects including reproductive toxicities. The Objective of this study was to evaluate the possible protective effects of lactoferrin (LFN) with anti-inflammatory and antioxidant properties against CP-evoked reproductive toxicity in mouse. Materials & methods: In this experimental study, 32 adult female NMRI mice were divided into 4 groups of 8. Cyclophosphamide was administered to two groups of mice at a dose of 200 mg/kg intraperitoneally on days 1 and 14. One of these groups received LFN at a dose of 0.2 mg/kg orally four hours after CP treatment. Vehicle-treated control group and LFN-only treated group were also included. In vitro fertilization was evaluated in all animals after 28 days. Findings: Cyclophosphamide administration resulted in significant reduction in fertilization and blastulation rates. Co-administration of LFN with CP restored above-mentioned parameters toward normal values. Discussion & conclusions: These findings indicate that LFN can have potential protective effects in CP-induced reprotoxicities. M3 10.29252/sjimu.25.5.100 ER -