AU - Saghaie, Parisa AU - Hasan zadeh, Shapoor AU - Malekinejad, Hasan AU - Shalizar jalali, Ali TI - Study of the Effects of Lactoferrin in Reduction of Cyclophosphamide-induced Embryotoxicity: In Vitro Fertilization Study in Mouse PT - JOURNAL ARTICLE TA - sjimu JN - sjimu VO - 25 VI - 5 IP - 5 4099 - http://sjimu.medilam.ac.ir/article-1-4422-en.html 4100 - http://sjimu.medilam.ac.ir/article-1-4422-en.pdf SO - sjimu 5 ABĀ  - Introduction: Cyclophosphamide (CP) as a widely used chemotherapeutic agent causes several side effects including reproductive toxicities. The Objective of this study was to evaluate the possible protective effects of lactoferrin (LFN) with anti-inflammatory and antioxidant properties against CP-evoked reproductive toxicity in mouse. Materials & methods: In this experimental study, 32 adult female NMRI mice were divided into 4 groups of 8. Cyclophosphamide was administered to two groups of mice at a dose of 200 mg/kg intraperitoneally on days 1 and 14. One of these groups received LFN at a dose of 0.2 mg/kg orally four hours after CP treatment. Vehicle-treated control group and LFN-only treated group were also included. In vitro fertilization was evaluated in all animals after 28 days. Findings: Cyclophosphamide administration resulted in significant reduction in fertilization and blastulation rates. Co-administration of LFN with CP restored above-mentioned parameters toward normal values. Discussion & conclusions: These findings indicate that LFN can have potential protective effects in CP-induced reprotoxicities. CP - IRAN IN - Dept of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran LG - eng PB - sjimu PG - 100 PT - Research YR - 2018