TY - JOUR T1 - Effect of Endurance Training on the Expression of the Muscle Fibronectin Type III Domain-Containing Protein 5 and CTRP15 Levels in the Male Rats TT - تاثیر تمرین استقامتی بر بیان ژن فیبرونکتین III-دامنه 5 و CTRP15 درموش های صحرایی نر JF - sjimu JO - sjimu VL - 28 IS - 1 UR - http://sjimu.medilam.ac.ir/article-1-6111-en.html Y1 - 2020 SP - 78 EP - 88 KW - CTRP15 KW - Endurance training KW - Fibronectin type III domain-containing protein 5 KW - Insulin resistance KW - Rat N2 - Introduction: The effect of exercise on skeletal muscle-derived factors and their effects on the body's metabolism has recently been the focus of attention. This study aimed to investigate the effect of endurance training on the gene expression of the muscle Fibronectin type III domain-containing protein 5 and CTRP15 levels in the male rats. Materials & Methods: This experimental study included 16 male adult Wistar rats with 8 weeks of age and mean weight of 213±15 gr. The rats were divided into two groups of endurance training (n=8) and control (n=8). The rats in the training group had 4-week endurance training sessions (5 sessions per week) including running on a treadmill for rodents for 45 min at the head of a certain time during the day and at the same time. On the other hand, the control group had no exercise. Initially, the Soleus muscle was homogenized and the expression of Fibronectin type III domain-containing protein 5 and CTRP15genes were measured by real-time polymerase chain reaction analysis. Subsequently, Irisin and insulin levels were measured using enzyme-linked immunosorbent assay and glucose levels were assessed by glucose oxidase. The data were analyzed by independent t-test and a p-value less than 0.05 was considered statistically significant. Findings: The results of this study showed a significant difference between the training and control groups regarding the expression of Fibronectin type III domain-containing protein 5 and CTRP15 gene in muscle after the endurance exercise (P=0.034 and P=0.048). In addition, the training group had higher Irisin serum level, compared to the control group (P=0.029). Although, insulin resistance obtained a 25% difference after four weeks of endurance training, it was not significant (P=0.500). Discussion & Conclusions: According to the results of the present study, it seems that mid-term endurance training can improve metabolism by increasing the levels of myokines. M3 10.29252/sjimu.28.1.78 ER -