%0 Journal Article %A Ghaderi, Arezoo %A Kohan, Leila %A Anvar, Zahra %T Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility %J Journal of Ilam University of Medical Sciences %V 26 %N 5 %U http://sjimu.medilam.ac.ir/article-1-4369-en.html %R 10.29252/sjimu.26.5.189 %D 2019 %K Idiopathic, Male infertility, UCP2, Polymorphism, %X Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del polymorphism with idiopathic male infertility. Materials & Methods: In this case-control study, UCP2 polymorphism was investigated in 196 individuals with idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis. Findings: No association was observed between UCP2 45bp ins/del polymorphism genotypes and risk of idiopathic male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0.08). Moreover, data analysis showed that I allele had protective effect against idiopathic male infertility (OR: 0.729, 95%CI: 0.54-0.985, P=0.039). Discussion & Conclusions: In this study, for the first time, we found that the I allele in UCP2 45bp ins/del polymorphism has protective effects against idiopathic male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results. %> http://sjimu.medilam.ac.ir/article-1-4369-en.pdf %P 189-195 %& 189 %! %9 Research %L A-10-2299-3 %+ Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran %G eng %@ 1563-4728 %[ 2019