TY - JOUR JF - sjimu JO - J. Ilam Uni. Med. Sci. VL - 21 IS - 2 PY - 2013 Y1 - 2013/6/01 TI - Comparison of metformin and pioglitazone on hs-CRP levels in patients with Type II diabetes TT - مقایسه اثر متفورمین و پیوگلیتازون بر سطح hs-CRP در بیماران مبتلا به دیابت نوع دو N2 - Background: Heart disease, particularly coronary heart disease is a major cause of mortality among patients with diabetes mellitus. High level of hs-CRP is considered as a risk factor for heart diseases. Treatment with pioglitazone in patients with or without type II diabetes decreases serum concentrations of hs-CRP. The purpose of this study was to compare the effects of pioglitazone and metformin on hs-CRP level. Material and methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and defined inclusion criteria. Patients were divided into two groups receiving metformin and pioglitazone. Blood levels of cholesterol, triglycerides, fasting blood glucose, Alanine transaminase, Aspartat aminotransferase, HbA1C and hs-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy were analyzed by paired T-test, the mean change between groups were compared by T-test. Results: In both groups, hs-CRP level was significantly decreased after drug therapy. The mean change of hs-CRP, HbA1C, cholesterol was significantly higher in metformin treated group. Conclusion: Since the average reduction in the level of hs-CRP, cholesterol and HbA1C in diabetic patients treated with metformin is significantly higher than patients treated with pioglitazone treatment with metformin is recommended to reduce risk of heart disease SP - 28 EP - 36 AU - Ziaee, Amir AU - Hashemipour, Sima AU - Ghavam, Samiramis AU - Javadi, Amir AU - Ghavam, Ramak AU - Barikani, Ameneh AU - Esmailzadehha, Neda AD - Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran KW - Diabetes mellitus KW - Metformin KW - Pioglitazone KW - hs-CRP KW - HbA1C UR - http://sjimu.medilam.ac.ir/article-1-596-en.html ER -