TI - The Effect of Intravenous Lidocaine Premedication and Slow Rate of Fentanyl Administration on Fentanyl – Induced Coughing PT - JOURNAL ARTICLE TA - sjimu JN - sjimu VO - 14 VI - 4 IP - 4 4099 - http://sjimu.medilam.ac.ir/article-1-55-en.html 4100 - http://sjimu.medilam.ac.ir/article-1-55-en.pdf SO - sjimu 4 AB  - Abstract Introduction: Intravenous (IV) administration of Fentanyl bolus elicits cough in more than one – third of the patients. Coughs may sometimes be explosive leading to hypoxia, vomiting, with increases in intracranial, intraocular and intraabdominal pressures. Materials & Methods: This double blind clinical trial included 360 patients below 60 years with ASA status I & II, who were scheduled for elective surgeries. They were randomized into 3 groups of 120. Group I received Normal Saline as placebo, 60 secounds late fentanyl was administred slowly over a period of 30 secounds. Group II was given fentanyl over 5 secounds, 1 minute after Lidocaine, (1.5 mg/kg IV). Group III also received Normal Salin, 60 secounds before the Fentanyl was given in 5 secounds. Fentanyl dose was 2 µg/kg. Then, incidence and severity of cough was recorded, and the results were analyzed using Chi square test. P.value of 0.05 was considered significant. Results: The incidence of cough was 2.5% in group I, 9.2% and 22.5% in groups II & III respectively. The finds showed that the incidence of cough was significantly higher in group III (P CP - IRAN IN - LG - eng PB - sjimu PG - 31 PT - Research YR - 2007