TI - Furazolidone, Amoxicillin, Omeprazole With or Without Bismuth for Eradication of Helicobacter Pylori in Peptic Ulcer Disease PT - JOURNAL ARTICLE TA - sjimu JN - sjimu VO - 18 VI - 2 IP - 2 4099 - http://sjimu.medilam.ac.ir/article-1-291-en.html 4100 - http://sjimu.medilam.ac.ir/article-1-291-en.pdf SO - sjimu 2 AB  - Introduction: Furazolidone has been introduced as an effective drug against helicobacter pylori infection in Iran, but intolerable side-effects may limit its use. We compared quadruple and triple furazolidone-based regimens to achieve an economically affordable regimen with acceptable efficacy rate and fewer complications. Matherials & Methods: Patients with H.pylori positive peptic ulcer disease were randomly divided into two groups. They were treated with amoxicillin 1gm/BID, furazolidone 200 mg/BID, omeprazole 20mg/BID with and without bismuth sub-citrate 240 mg/BID for two weeks (AFOB & AFO regimens, respectively) H.pylori eradication was confirmed by 13C-urea breath test 12 weeks after the end of the treatment. Findings: Eighty six patients were enrolled but 16 ones discontinued their therapy or follow-up. The eradication rates in AFOB & AFO were 85.3% and 61.1% by per-protocol analysis, respectively (P=0.02), and 67.4% & 51.2% by intention–to-treat analysis respectively (P CP - IRAN IN - LG - eng PB - sjimu PG - 30 PT - Research YR - 2010