TY - JOUR T1 - Histological changes in respiratory epithelium of right and left nasal cavities to Capsaicin in rat nasal mucosa. TT - تغییرات بافتی اپی تلیوم تنفسی حفرات راست و چپ بینی در پاسخ به کپسایسین در موش صحرایی JF - sjimu JO - sjimu VL - 15 IS - 1 UR - http://sjimu.medilam.ac.ir/article-1-18-en.html Y1 - 2007 SP - 32 EP - 38 KW - Nasal Cavity KW - respiratory epithelium KW - capsaicin KW - right KW - left. N2 - Abstract: Introduction: Nasal cycle, rhinitis and ipsilateral nasal polyps are seen in many Individuals. These effects are caused by changes made by vascular and neural tone releasing some neurohormones and vasoactive substances.Recently possible contribution of inflammatory mediators in nasobronchial reflexes have been reported by some studies. Their exact mechanisms are not determined yet. Material and methods: One hundred fourteen male N-MRI rats have been divided as control and inflammation test groups in the groups of six rats. Severity of inflammation was measured 6 (acute) and 24 (chronic) hours after insertion of micropads- moistured with saline or 50 & 100μg Capsaicin- into nasal middle turbinate. For the assessment of the inflammation and its mechanism, intraperitoneal (i.p) injection of 2 & 5 mg/kg Monteluckast (common Luckotrien receptor antagonist) was applied. Results: Saline (control) compared to intact group caused significant increase in mucus secretion of right (R) and left (L) nasal cavities (28 & 36µl, respectively) (P M3 ER -