TI - Effects of Pistachio Nut Powder on Rat LiverPhosphatidate Phosphohydrolase andSerum Lipids and Lipoproteins Profile PT - JOURNAL ARTICLE TA - sjimu JN - sjimu VO - 16 VI - 1 IP - 1 4099 - http://sjimu.medilam.ac.ir/article-1-17-en.html 4100 - http://sjimu.medilam.ac.ir/article-1-17-en.pdf SO - sjimu 1 ABĀ  - Abstract Introduction: Although the consumption of chemical drugs such as clofibrate and statins reduce serum lipids, they have undesirable side effects. So, at the present time the use of medicinal plants are preferred, because they are cheap, beneficially effective and of low undesirable side effects. The nuts of Anacardiace family have hypolipidemic effects on serum lipid profile by unknown mechanisms. Phosphatidate phosphohydrolase (PAP) is a key regulator enzyme in lipid metabolism. Therefore, the aim of this study is to determine effects of Pistacia khinjuk nut on PAP, serum lipid profile and liver content triglyceride in rats. Materials and Methods: Four groups of rats (n=6/group) were fed with normal diet (control) or normal diet plus 10% pistachio nut powder for 15 and 60 days . Then, PAP activity, triglyceride, total cholesterol, HDL-cholesterol, LDL- cholesterol, VLDL- cholesterol, and liver content triglyceride were measured. Findings: Feeding rats with pistachio nut for 15 days had significant elevated cholesterol in all lipoprotein fractions and reduced liver content triglyceride (P< 0.05). Although, PAP activity reduced approximately 11%, it was not significant in control group (P>0.05). On the other hand, rats fed with pistachio nut for 60 days had no significant differences with control group in all lipoprotein fractions (P>0.05), whereas the liver content triglyceride significantly decreased(P CP - IRAN IN - LG - eng PB - sjimu PG - 47 PT - Research YR - 2008