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Comparison of metformin and pioglitazone on hs-CRP levels in patients with Type II diabetes
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Amir Ziaee1   , Sima Hashemipour1 , Samiramis Ghavam2 , Amir Javadi1 , Ramak Ghavam * 3, Ameneh Barikani1 , Neda Esmailzadehha1 |
1- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran
2- Ilam University of Medical Sciences
3- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran , ramak.ghavam@yahoo.com |
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Abstract: (28332 Views) |
| Background: Heart disease, particularly coronary heart disease is a major cause of mortality among patients with diabetes mellitus. High level of hs-CRP is considered as a risk factor for heart diseases. Treatment with pioglitazone in patients with or without type II diabetes decreases serum concentrations of hs-CRP. The purpose of this study was to compare the effects of pioglitazone and metformin on hs-CRP level.
Material and methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and defined inclusion criteria. Patients were divided into two groups receiving metformin and pioglitazone. Blood levels of cholesterol, triglycerides, fasting blood glucose, Alanine transaminase, Aspartat aminotransferase, HbA1C and hs-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy were analyzed by paired T-test, the mean change between groups were compared by T-test.
Results: In both groups, hs-CRP level was significantly decreased after drug therapy. The mean change of hs-CRP, HbA1C, cholesterol was significantly higher in metformin treated group.
Conclusion: Since the average reduction in the level of hs-CRP, cholesterol and HbA1C in diabetic patients treated with metformin is significantly higher than patients treated with pioglitazone treatment with metformin is recommended to reduce risk of heart disease |
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| Keywords: Diabetes mellitus, Metformin, Pioglitazone, hs-CRP, HbA1C |
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Full-Text [PDF 217 kb]
(6859 Downloads)
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Type of Study: Research |
Subject:
gp
Received: 2012/04/18 | Accepted: 2013/08/6 | Published: 2013/09/1
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