The Effect of Compulsory Sports Activities on Substantia Nigra
Tissue and Behavioral Tests Induction Parkinsons
Model with 6-Hydroxydopamine
in Prenatal Stress Rats
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Toraj Mohammad zamani1 , Ahmadreza Movahedi * 2, Elahe Arab ameri3 |
1- Dept of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran 2- Dept of Motor Behavior, Faculty of Physical Education, University of Isfahan, Isfahan, Iran , armovahedi@yahoo.com 3- Dept of Motor Behavior, Faculty of Physical Education, university of Tehran, Tehran, Iran |
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Abstract: (3924 Views) |
Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress. Exercising activity is a good way to prevent the disease. The aim of this study was to investigate the effect of mandatory exercise on Substantia nigra tissue in Perinatal Parkinson's rats.
Materials & Methods: A Laboratory research method was used. 48 Wistar male rats, half of them under prenatal stress And followed up on compulsory sports activities. Were divided into 8 groups of 6, with stress (control, sham, Parkinson, Parkinson + compulsory exercise) and without stress (control, sham, Parkinson, Parkinson + compulsory exercise). the animals received Stereotaxic Surgery after 8 weeks, Three weeks later, Parkinson's symptoms were evaluated using Apo morphine rotation test and Wire grasping. The number of substantia nigra neurons in the brain is counted using a microscope; Data were analyzed using One-Way ANOVA and Tukey's Post Test.
Ethics code: IR.IAU.SRB.REC.1396
Findings: In groups with and without stress, the number of substantia nigra neurons compulsory sports group was different from that of the control group and this difference was statistically significant (P=0.0000). The average number of substantia nigra neurons compulsory sports group in both groups with and without stress difference was low, but statistically significant (P=0.014).
Discussion & conclusions: The results refer to the effects of compulsive exercise on the better protection of Substantia nigra neurons and suggests that exercise can be effective as a beneficial factor in reducing the degeneration of dopaminergic neurons in Parkinson's disease. Prenatal stress also reduces the beneficial effects of exercise.
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Keywords: Compulsory sports, Prenatal stress, Substantia nigra tissue, Parkinson’s disease |
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Full-Text [PDF 1060 kb]
(1430 Downloads)
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Type of Study: Research |
Received: 2018/06/2 | Accepted: 2018/10/15 | Published: 2019/03/15
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