:: Volume 27, Issue 1 (4-2019) ::
sjimu 2019, 27(1): 192-202 Back to browse issues page
Effect of high Intensity Interval Training on Adiponectin Leptin Ratio and C‌‌‌-Reactive Protein in Streptozotocin Nicotinamide Induced Diabetic Rats
Mohammad Parastesh 1, Abbas Saremi2
1- Arak univercity , mohamad.parastesh@gmail.com
2- Dept of Sport Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran
Abstract:   (1320 Views)

Introduction: Changes in plasma adipicin and inflammatory parameters in type 2 diabetes are due to obesity and directly related to the condition of diabetes. The aim of this study was to investigate the effect of High intensity interval training (HIIT) on the ratio of adiponectin to leptin and C-reactive protein (CRP) in type 2 diabetic rats.

Materials & Methods: In this experimental study, 42 Wistar rats with mean weight of 205±54 were randomly assigned to healthy control, diabetic control and diabetic training groups. The diabetic training group received ten weeks of HIIT training following the induction of diabetes. At the end of the experimental period, blood samples were taken to assess leptin, adiponectin and insulin resistance. Data were analyzed by one-way ANOVA and Tukeychr('39')s post hoc test at a significant level of 0.05%.
Findings: The induction of diabetes by streptozotocin-nicotinamide resulted in a significant decrease in adiponectin (P =0.000) and leptin (P=0.000) and a significant increase in C-reactive protein (P=0.000) in diabetic control group compared to healthy control group Became 10 weeks of HIIT training resulted in a significant decrease in fasting blood glucose (P=0.109), C-reactive protein (P=0.024), and a significant increase in serum leptin levels (P=0.001), adiponectin (P=0.42) In the HIIT training group compared to the diabetic control group.
Discussion & Conclusions: It seems that HIIT training improves inflammation (C-reactive protein) in type 2 diabetic rats by altering serum levels of adiponectin and leptin. In the present study, 10 weeks of HIIT training led to an increase in the ratio of adiponectin to leptin and consequent reduction of C-reactive protein.
Keywords: Type 2 diabetic, Adiponectin/leptin ratio, C‌‌-reactive protein, HIIT training
Full-Text [PDF 1011 kb]   (340 Downloads)    
Type of Study: Research |
Received: 2018/03/31 | Accepted: 2018/09/11 | Published: 2019/04/15

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Volume 27, Issue 1 (4-2019) Back to browse issues page