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:: Volume 25, Issue 6 (3-2018) ::
sjimu 2018, 25(6): 54-62 Back to browse issues page
Verification of Activity Accumulation Location Effect in Patients Treated with I-131 Radio Pharmacy on the Evaluated Exposure at Different Distances from Patient using NCAT Phantom
Mahin Kokhazadeh Miss. 1, Hossein Rajabi Mr.2, Samira Rasaneh Ms.3, Mohammad ali Askari Mr.4, Parisa Taheri Miss.4
1- Master of Science Dept of Physical Physic, Faculty o Medical Sciences, Tarbiatmodares University, Tehran, Iran , mahin_kookhazadeh@yahoo.com
2- Associate Professor Dept of Physical Physic, Faculty o Medical Sciences, Tarbiatmodares University, Tehran, Iran
3- PhD Institute for Research in Technology and Nuclear Science, Tehean, Iran
4- PhD .student Dept of Physical Physic, Faculty o Medical Sciences, Tarbiatmodares University, Tehran, Iran
Abstract:   (516 Views)

Introduction: One of the most common applications of medical isotopes is in treatment of cancer and hyperthyroidism using Iodine-131. The Iodine-131 cumulates in cancerous cells and acts as a source of radioactive emissions. Apparently, local and temporal distributions of the radioactive material are different in various organs. In this paper, the effect of radioactive Iodine distribution on the amount of exposure at different distances has been investigated.
 
Materials & Methods: This analysis has been carried out using adult NCAT phantoms, Monte-Carlo simulation, and GATE code. By applying the same amount of activity on five different organs of the phantom, the quality and quantity of energy has been computed as well as the amount of emitted exposures at distances of one, two, and three meters. Then, by setting thyroid as the basis, the difference of exposure emitted from other four organs has been calculated and analyzed using KS test.
 
Findings: Simulation results had been showed that the amounts of exposure that emitted from aforementioned organs are significantly different at the distance of one meter whereas this difference diminishes significantly at distances of two and three meters. In other words, the effect of radioactive Iodine integration location on the emitted exposure is being trivial as the distance increases.
 
Discussion & Conclusions: Distinct TEDE values must be defined for each of the aforementioned organs and confirmed before releasing patients who will be faced to the others at short distances. Otherwise, guidelines must be considered for the others who will be faced to the released patient.

Keywords: Thyroid cancer, Hyperthyroidism, Iodine-131, Exposure, NCAT phantom, Monte-carlo simulation, GATE code
Full-Text [PDF 841 kb]   (107 Downloads)    
Type of Study: Applicable | Subject: Medical physics
Received: 2015/11/17 | Accepted: 2015/11/25 | Published: 2018/03/5
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Kokhazadeh M, Rajabi H, Rasaneh S, Askari M A, Taheri P. Verification of Activity Accumulation Location Effect in Patients Treated with I-131 Radio Pharmacy on the Evaluated Exposure at Different Distances from Patient using NCAT Phantom . sjimu. 2018; 25 (6) :54-62
URL: http://sjimu.medilam.ac.ir/article-1-3192-en.html


Volume 25, Issue 6 (3-2018) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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