Introduction: Mesial temporal lobe epilepsy is one of the most common complex partial syndromes which its common treatment is medication. The present study aims at comparing the efficacy of drug therapy and drug therapy combined with neurofeedback on decrement of severity of epileptic symptoms in patients with refractory left temporal lobe epilepsy in Isfahan city.

Materials & methods: This is a single case study, with MBD design and multiple baselines, in which two patients with refractory left temporal lobe epilepsy were recruited from Masih Epilepsy Centre in Isfahan city. The subjects were entered to MBD design after the baseline phase. They received 30 sessions of neurofeedback individually, and two weeks after the intervention, they were reassessed in the follow up phase for three consequent weeks. Scale of Temporal Lobe Epilepsy Symptoms" was used to collect the data.

Findings: The results showed that according to the visual analysis of the data, neurofeedback intervention was effective for both of the patients, with PND 100% for the first patient, and PND 90% for the other. The decrement of severity of epileptic symptoms was maintained constant three weeks following the intervention.

Discussion & conclusions: The findings suggest that neurofeedback is effective on decrement of severity of epileptic symptoms in patients with refractory temporal lobe epilepsy in Isfahan city.