:: Volume 24, Issue 2 (6-2016) ::
sjimu 2016, 24(2): 130-138 Back to browse issues page
The Effect of Alcoholic Extract of Smyrnium cordifolium Boiss Root on Prevention of Ethylene Glycol-Induced Kidney Calculi in Rats
Mahbobeh Adhamian esfehani1, Leila Rouhi 2, Shahrzad Azizi3
1- Dept of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch , Shahrekord, Iran
2- Dept of Animal Physiology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch , Shahrekord, Iran , Lrouhi59@gmail.com
3- Dept of Pathobiology, Faculty of Veterinary, Shahid Bahonar University of Kerman, Kerman, Iran
Abstract:   (5143 Views)

Introduction: Considering the evidence which show the effect of herbal medicine on nephrolithiasis treatment, the aim of this study was to evaluate the efficacy of ethanolic extract of Smyrnium cordifolium Boiss root on prevention of calcium oxalate nephrolithiasis in rats.

Materials & methods:  Thirty-two female Wistar albino rats were randomly divided into 4 groups. Normal control received water and other three groups received ethylene glycol (EG) (1% v/v) in distilled water for 28 days. Extract was given 200 mg/kg and 400 mg/kg orally in distilled water for 28 days in groups III and IV. The urea, uric acid and creatinine were measured on 28th day. 24 hr urinary volume and oxalate were measured on day 0 and 28.

Findings: EG significantly had increased serum creatinine, urea and uric acid in comparison to the normal control. Whereas serum creatinine, urea and uric acid were reduced non-significantly in groups III and IV in comparison to EG group. Smyrnium cordifolium extract significantly increased urinary volume but decreased urine oxalate level compared to EG group (P<0.05).

Discussion & Conclusions: This study showed that Smyrnium cordifolium extract was able to reduce urine oxalate in the rat. Therefore, the beneficial action of extract on human kidney stones may be suggested. However, further studies must clarify the mechanism.

Keywords: Smyrnium cordifolium, Boiss root, Nephrolithiasis, Ethyleneglycol, Calcium oxalate
Full-Text [PDF 699 kb]   (14069 Downloads)    
Type of Study: Research | Subject: biology
Received: 2015/08/17 | Accepted: 2015/10/3 | Published: 2016/06/26



XML   Persian Abstract   Print



Volume 24, Issue 2 (6-2016) Back to browse issues page