Introduction: Today, job burnout and effective variables on its reduction or increase is one of the most important issues in human resource management. The relationship between key variables of psychological empowerment and quality of work life with job burnout is effective in solving problems of human resources and promotion of organization.

Materials & methods: This study is descriptive and correlational. The study population included all health experts working in the health deputy of University of Medical Sciences in 2014. According to Krejcie & Morgan’s table (1970), the sample size determined equal to 148, which were selected using stratified sampling method. The tools used in the study were the standard psychological empowerment inventory of Spreitzer (1995), Walton’s questionnaire of quality of work life (1973), Maslach’s Job Burnout (1985) and a checklist made by the author. After collecting data, SPSS 22 and descriptive statistics were used to calculate the mean and related tables. Inferential statistics such as Kolmogorov-Smirnov, Pearson correlation coefficient, linear regression and variance analysis tables were used for the analysis of data.

Findings: There is a significant inverse relationship between psychological empowerment and job burnout of health experts (r=0.280). Among dimensions of empowerment only the corresponding t with β of job was significant with coefficient of -0.314 in the error level of fewer than 5%. There is also a significant inverse relationship between quality of work life and job burnout of health experts (r=-0.154) and among dimensions of quality of work life only the corresponding t with β of providing opportunity of growth with coefficient of -0.379 was significant at the error level of fewer than 5%.

Discussion & conclusion: These results indicated the importance of effective interventions in the field of implementing education programs on employee empowerment and improvement of the quality of work life with an emphasize on significant dimensions of job and providing growth opportunities in order to prevent job burnout among health experts by managers and planners of this field.