:: Volume 18, Issue 4 (1-2011) ::
sjimu 2011, 18(4): 27-34 Back to browse issues page
Serum Concentration of Leptin And Adiponectin in Preeclampsia
Abstract:   (9679 Views)

Introduction: Preeclampsia, a pregnancy specific syndrome, is a major cause of maternal and perinatal morbidity and mortality. The aim of the present study was to assess relationship between leptin and adiponectin, and leptin/adiponectin ratio in preeclamptic women compared with normal pregnant women. Materials & Methods: A cross-sectional study was designed. The patients consisted of 30 preeclamptic women. The control group consisted of 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay (ELISA) methods. The unpaired Student’s t-test and Pearson’s correlation analysis were used for statistical analysis. Findings: Serum levels of leptin were significantly higher in preeclamptic group than in normal control group, while adiponectin levels decreased. There was a significant negative correlation between leptin and adiponectin in normal control group and also in preeclamptic women. The leptin/adiponectin ratio increased significantly in preeclamptic patients. Discussion & Conclusion: The findings of the present study suggest that increase in leptin and decrease in adiponectin levels can help as a biomarker for diagnosis of severe preeclampsia.

Keywords: Keywords: leptin, adiponectin, preeclampsia
Full-Text [PDF 266 kb]   (2071 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/03/15 | Accepted: 2015/04/8 | Published: 2015/04/8

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Volume 18, Issue 4 (1-2011) Back to browse issues page