Introduction: According to the progress of diabetes and the use of alternative herbal medicines, in this study, the effect of Petroselinum crispum parsley leaf  hydroalcoholic extract on histopathological and liver enzymatic activity were examined.

Materials & methods : In this study, 60 male wistar rats with the weight range of 250-300 g were divided randomly into 5 groups of treatment. After the necessary treatments tested on animals , blood and liver samples were collected . Activity of liver enzymes AST, ALT, ALP was measured . The microscopic sections were prepared from the liver and the pathological tissue was investigated .

Findings: Activity of liver enzymes (ALT, AST, ALP) in the diabetic group compared to non-diabetic controls showed a significant increase (p<0.01). The intervention of parsley leaves extract resulted in a significant decrease in the activity of the enzyme and repair damaged liver tissue in diabetic rats was (p<0.01).

Discussion & Conclusions: The findings showed that the extract of parsley leaves in diabetic rats can modulate the activity of the hepatic enzymes. Healing effect of the extract in the case of diabetes on liver histopatology was remarkable. The pharmacological properties and anti-inflammatory protective effect of the parsley might be used to prevent hepatitis caused by diabetes.