[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 23, Issue 7 (2-2016) ::
sjimu 2016, 23(7): 190-202 Back to browse issues page
The Effect of Ethanolic Extracts of Petroselinum crispum Leaves on Histopathological and Activity of Liver Enzymes in Streptozotocin-Induced Diabetic Rats
Javad Cheraghi 1, Parisa Krishchi 2, Sima Nasri 3, Masoumeh Boorboor 4
1- assistant prof. Ilam University , j.cheraghi@ilam.ac.ir
2- assistant prof. Islamic Azad University, Tehran
3- assistant prof. Payame Noor University, Tehran
4- MSc Payame Noor University, Tehran
Abstract:   (2427 Views)

Introduction: According to the progress of diabetes and the use of alternative herbal medicines, in this study, the effect of Petroselinum crispum parsley leaf  hydroalcoholic extract on histopathological and liver enzymatic activity were examined.

Materials & methods : In this study, 60 male wistar rats with the weight range of 250-300 g were divided randomly into 5 groups of treatment. After the necessary treatments tested on animals , blood and liver samples were collected . Activity of liver enzymes AST, ALT, ALP was measured . The microscopic sections were prepared from the liver and the pathological tissue was investigated .

Findings: Activity of liver enzymes (ALT, AST, ALP) in the diabetic group compared to non-diabetic controls showed a significant increase (p<0.01). The intervention of parsley leaves extract resulted in a significant decrease in the activity of the enzyme and repair damaged liver tissue in diabetic rats was (p<0.01).

Discussion & Conclusions: The findings showed that the extract of parsley leaves in diabetic rats can modulate the activity of the hepatic enzymes. Healing effect of the extract in the case of diabetes on liver histopatology was remarkable. The pharmacological properties and anti-inflammatory protective effect of the parsley might be used to prevent hepatitis caused by diabetes.

Keywords: Petroselinum crispum, Hepatic enzymes, Diabetes, Rat
Full-Text [PDF 1177 kb]   (1420 Downloads)    
Type of Study: Research | Subject: physiology
Received: 2014/11/16 | Accepted: 2015/08/26 | Published: 2016/03/7
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

cheraghi J, krishchi P, nasri S, boorboor M. The Effect of Ethanolic Extracts of Petroselinum crispum Leaves on Histopathological and Activity of Liver Enzymes in Streptozotocin-Induced Diabetic Rats. sjimu. 2016; 23 (7) :190-202
URL: http://sjimu.medilam.ac.ir/article-1-2292-en.html


Volume 23, Issue 7 (2-2016) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.22 seconds with 31 queries by YEKTAWEB 3705