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Frequency of Celiac Disease in Patients with Diarrhea Predominant Irritable Bowel Syndrome Referred to Gastroenterology Clinics in Ilam During 2008 to 2012
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A Jafri haidarlo   , Ar Mahmodi , M Yasemi , A Baziar , S Ehsan bakhsh , M Rashid begi * 1 |
| 1- , miladrashidbeygi@yahoo.com |
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Abstract: (12141 Views) |
| Introduction: Several studies showed inc-reased prevalence of celiac disease (CD) in irritable bowel syndrome (IBS) how-ever, the evidence is conflicting and often dose not propose to explor CD in the patients. This study aimed to investigate the preval-ence of CD in patients with diarrhea pred-ominant IBS.
Materials & Methods: The present research was a descriptive cross-sectional study that performed on 1000 IBS patients with diarrhea- predominant clinical picture refe-rred to a gastroenterology clinic in Ilam during 2008 to 2012. Blood samples were taken from all patients to assay IgA to tiss-ue transglutaminase (IgA anti tTG) by ELI-SA method. Biopsies samples from the sec-ond part of duodenum in the patients were provided by endoscopiy and sent to patholy clinic for histopathological evaluation and final diagnosis.
Finding: The mean age of men and women participating in the study were 11.41±29.59 and 11.73±28.42 years, respectively. More than half of the participants were female (50.3%). The mean titer of IgA anti tTG in men and women with IBS were 17.17±5.25 and 25.4±7.22 U/mL, respectively. 76 IBS patients had high antibody titers (IgA anti tTG ≤10), among which 41 patients were female and 35 patients were male. Among the patients with high antibody titer, 57 subjects (75%) had CD (based on histo-logical findings). The prevalence of CD was 5.7% among the patients with IBS.
Discussion & Conclusion: The results of this study suggested that all IBS patients with diarrhea-predominant clinical picture are needed to examine for the presence of CD. The diagnostic approach presented in this study may also be useful in the asses-ssment of CD. |
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| Keywords: celiac disease, irritable bowel syndrome, anti body |
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Full-Text [PDF 418 kb]
(9820 Downloads)
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Type of Study: Research |
Subject:
Internal operations( nursing )
Received: 2013/10/14 | Accepted: 2013/10/20 | Published: 2013/10/20
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