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:: Volume 21, Issue 1 (5-2013) ::
Journal of Ilam University of Medical Sciences 2013, 21(1): 89-96 Back to browse issues page
The Association Between Telomeres, Telomerase, Cancer and Aging
M Hamidi , N a Ahmadi * 1, S Bastami nejad
1- , nayebalia@sbmu.ac.ir;
Abstract:   (24317 Views)
Telomere is physically terminal of linear chromosomes composed of a non-coding sequence. Mammalian telomeres consist of a variable number of repeated sequences (TTAAGGG) that is added by telomerase to the 3' end of chromosomes. Telomeres pro-tect chromosomes from degradation, chro-mosome attachment to chromosomes and prevent other forms of defective reco-mbination. Despite the contradictory role of telomerase dysfunction in specific genetic diseases, association between telomere dys-function with aging is now open for disc-ussion. The most common way for cancer cells to achieve their specific development into tumor formation is probably through terlomerase activation. Clarify the comple-xities of controlling telomerase may prov-ide a route to target telomerase activity as a routine method of treatment for many pati-ents with cancer and be considered as a target for therapeutics. In this paper, we have a brief look at the structure and fun-ction of telomere and telomerase and then the link between telomerase activity in agi-ng and cancer, and the relationship between different aspects have been investigated in detail. In addition the other roles of telo-merase in the body are discussed. Finally, the use of telomerase as a drug target in cancer therapy has been considered.
Keywords: telomeres, telomerase, cancer, aging
Full-Text [PDF 363 kb]   (8377 Downloads)    
Type of Study: Research | Subject: Bacteriology
Received: 2013/06/2 | Accepted: 2013/09/1 | Published: 2013/09/1
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hamidi M, ahmadi N A, bastami nejad S. The Association Between Telomeres, Telomerase, Cancer and Aging. J. Ilam Uni. Med. Sci. 2013; 21 (1) :89-96
URL: http://sjimu.medilam.ac.ir/article-1-1025-en.html


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Volume 21, Issue 1 (5-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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