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:: Volume 25, Issue 2 (7-2017) ::
sjimu 2017, 25(2): 156-165 Back to browse issues page
Study of Troponin and Creatinine Kinase Changes Associated with Heart and Brain Pathological Lesions Due to Experimental Toxicity of Nerium oleander in Wistar Rat
Sara Basiri Dr1, Monire Khordadmehr Dr2, Roya Shahbazi Ms2, Maryam Mansourian Dr 3
1- Dept of Food hygiene, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran
2- Dept of Pathobiology, Faculty of Veterinary Medicine, Tabriz University, Tabriz, Iran
3- Razi Vaccine and Serum Research Institute, Shiraz, Iran , marymansourian20@gmail.com
Abstract:   (1328 Views)

Introduction: Nerium oleander is widely cultivated around the word, and also it is found across our country. All parts of this plant are considered toxic and can poison humans and livestock. The present study was carried out to study cardiac and neurotoxicity effects of oral administration of N. oleander extract in Wistar rat.

Materials & methods: In this study, the toxic effects of this plant were determined by measuring serum levels of the biochemical parameters including troponin and creatinine kinase (CK). Moreover, histopathological examination was performed on the vital organs including heart and brain.

Findings: CK and troponin were 6-7 and 11 times higher in comparison with control group (P<0.05), respectively. In the heart, hyperemia, hemorrhage and myofibrolysis were observed without infiltration of inflammatory cells. Pathological lesions in the brain included hyperemia associated with perivascular and perineuronal edema. Interestingly, in rats with higher toxicity doses, multifocal hemorrhage and liqufactive necrosis were seen in the brain.

Discussion & conclusions: According to results of the present study, it seems that N. oleander poisoning can induce acute cardiac toxicity and neurotoxicity which are confirmed with the present biochemical and histopathological findings.

Keywords: Nerium oleander, Troponin, CK (Creatinine kinase), Histopathology
Full-Text [PDF 564 kb]   (846 Downloads)    
Type of Study: Research | Subject: biochemistry
Received: 2016/10/12 | Accepted: 2017/01/7 | Published: 2017/07/18
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Basiri S, Khordadmehr M, Shahbazi R, Mansourian M. Study of Troponin and Creatinine Kinase Changes Associated with Heart and Brain Pathological Lesions Due to Experimental Toxicity of Nerium oleander in Wistar Rat. sjimu. 2017; 25 (2) :156-165
URL: http://sjimu.medilam.ac.ir/article-1-3872-en.html


Volume 25, Issue 2 (7-2017) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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